Focal seizures are organized by feedback between neural activity and ion concentration changes.

ABSTRACT: Human and animal EEG data demonstrate that focal seizures start with low-voltage fast activity, evolve into rhythmic burst discharges and are followed by a period of suppressed background activity. This suggests that processes with dynamics in the range of tens of seconds govern focal seizure evolution. We investigate the processes associated with seizure dynamics by complementing the Hodgkin-Huxley mathematical model with the physical laws that dictate ion movement and maintain ionic gradients. Our biophysically realistic computational model closely replicates the electrographic pattern of a typical human focal seizure characterized by low voltage fast activity onset, tonic phase, clonic phase and postictal suppression. Our study demonstrates, for the first time in silico, the potential m

SUBMITTER: Gentiletti D 

PROVIDER: S-EPMC9377802 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature