High-Risk Drinkers Engage Distinct Stress-Predictive Brain Networks.

ABSTRACT:

Background

Excessive alcohol intake is a major public health problem and can be triggered by stress. Heavy drinking in patients with alcohol use disorder also alters neural, physiological, and emotional stress responses. However, it is unclear whether adaptations in stress-predictive brain networks can be an early marker of risky drinking behavior.

Methods

Risky social drinkers (regular bingers; n = 53) and light drinker control subjects (n = 51) aged 18 to 53 years completed a functional magnetic resonance imaging-based sustained stress protocol with repeated measures of subjective stress state, during which whole-brain functional connectivity was computed. This was followed by prospective daily ecological momentary assessment for 30 days. We used brain computational predic

SUBMITTER: Goldfarb EV 

PROVIDER: S-EPMC9378362 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature