Comparison of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis in children at a resource limited setting of South Punjab, Pakistan.

ABSTRACT:

Objectives

To compare the efficacy of Ondansetron versus Domperidone for treating vomiting in acute gastroenteritis (AGE) in children at a resource limited emergency setting of South Punjab, Pakistan.

Methods

This open label randomized controlled trial was conducted at The Pediatric Emergency Department of Tehshil Headquarter Hospital, Liaqatpur, Pakistan, from July 2020 to June 2021. A total of 300 children of both genders aged below 12 years of age having 3 or more non-bilious, non-bloody vomiting episodes within 24 hours and with suggestive signs and symptoms of AGE were enrolled and randomized (150 in each group). Efficacy of both drugs was compared in terms of need of 2^nd dose within 15 minutes, cessation of vomiting at 6-hour and 24-hour follow up.

Result

SUBMITTER: Ahmad T 

PROVIDER: S-EPMC9378405 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature