Brain Structure and Function Predict Adherence to an Exercise Intervention in Older Adults.

ABSTRACT:

Introduction

Individual differences in brain structure and function in older adults are potential proxies of brain reserve or maintenance and may provide mechanistic predictions of adherence to exercise. We hypothesized that multimodal neuroimaging features would predict adherence to a 6-month randomized controlled trial of exercise in 131 older adults (age, 65.79 ± 4.65 yr, 63% female), alone and in combination with psychosocial, cognitive, and health measures.

Methods

Regularized elastic net regression within a nested cross-validation framework was applied to predict adherence to the intervention in three separate models (brain structure and function only; psychosocial, health, and demographic data only; and a multimodal model).

Results

Higher cortical thickness in

SUBMITTER: Morris TP 

PROVIDER: S-EPMC9378462 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature