Race, Genotype, and Azathioprine Discontinuation : A Cohort Study.

ABSTRACT:

Background

Thiopurines are an important class of immunosuppressants despite their risk for hematopoietic toxicity and narrow therapeutic indices. Benign neutropenia related to an ACKR1 variant (rs2814778-CC) is common among persons of African ancestries.

Objective

To test whether rs2814778-CC was associated with azathioprine discontinuation attributed to hematopoietic toxicity and lower thiopurine dosing.

Design

Retrospective cohort study.

Setting

Two tertiary care centers.

Patients

Thiopurine users with White or Black race.

Measurements

Azathioprine discontinuation attributed to hematopoietic toxicity. Secondary outcomes included weight-adjusted final dose, leukocyte count, and change in leukocyte count.

Results

The rate of azathiop

SUBMITTER: Dickson AL 

PROVIDER: S-EPMC9378477 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature