Traumatic Brain Injury and Risk of Alzheimer's Disease and Related Dementias in the Population.

ABSTRACT:

Background

Epidemiological studies examining associations between traumatic brain injury (TBI) and Alzheimer's disease and related dementias (ADRD) have yielded conflicting results, which may be due to methodological differences.

Objective

To examine the relationship between the presence and severity of TBI and risk of ADRD using a population-based cohort with medical record abstraction for confirmation of TBI and ADRD.

Methods

All TBI events among Olmsted County, Minnesota residents aged > 40 years from 1985-1999 were confirmed by manual review and classified by severity. Each TBI case was randomly matched to two age-, sex-, and non-head injury population-based referents without TBI. For TBI events with non-head trauma, the Trauma Mortality Prediction Model was appli

SUBMITTER: Mielke MM 

PROVIDER: S-EPMC9378485 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature