Cerebellar Structure and Cognitive Ability in Psychosis.

ABSTRACT:

Background

Dysconnectivity theories, combined with advances in fundamental cognitive neuroscience, have led to increased interest in characterizing cerebellar abnormalities in psychosis. Smaller cerebellar gray matter volume has been found in schizophrenia spectrum disorders. However, the course of these deficits across illness stage, specificity to schizophrenia (vs. psychosis more broadly), and relationship to clinical phenotypes, primarily cognitive impairment, remain unclear.

Methods

The Spatially Unbiased Infratentorial toolbox, a gold standard for analyzing human neuroimaging data of the cerebellum, was used to quantify cerebellar volumes and conduct voxel-based morphometry on structural magnetic resonance images obtained from 574 individuals (249 schizophrenia spectru

SUBMITTER: Moussa-Tooks AB 

PROVIDER: S-EPMC9378489 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature