Reorganization of Ventral Premotor Cortex After Ischemic Brain Injury: Effects of Forced Use.

ABSTRACT:

Background

Physical use of the affected upper extremity can have a beneficial effect on motor recovery in people after stroke. Few studies have examined neurological mechanisms underlying the effects of forced use in non-human primates. In particular, the ventral premotor cortex (PMV) has been previously implicated in recovery after injury.

Objective

To examine changes in motor maps in PMV after a period of forced use following ischemic infarct in primary motor cortex (M1).

Methods

Intracortical microstimulation (ICMS) techniques were used to derive motor maps in PMV of four adult squirrel monkeys before and after an experimentally induced ischemic infarct in the M1 distal forelimb area (DFL) in the dominant hemisphere. Monkeys wore a sleeved jacket (generally 24 hrs/

SUBMITTER: Frost SB 

PROVIDER: S-EPMC9378490 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature