Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial Infection.

ABSTRACT: Influenza-associated bacterial superinfections have devastating impacts on the lung and can result in increased risk of mortality. New strains of influenza circulate throughout the population yearly, promoting the establishment of immune memory. Nearly all individuals have some degree of influenza memory before adulthood. Due to this, we sought to understand the role of immune memory during bacterial superinfections. An influenza heterotypic immunity model was established using influenza A/Puerto Rico/8/34 and influenza A/X31. We report in this article that influenza-experienced mice are more resistant to secondary bacterial infection with methicillin-resistant Staphylococcus aureus as determined by wasting, bacterial burden, pulmonary inflammation, and lung leak, despite significan

SUBMITTER: Cipolla EM 

PROVIDER: S-EPMC9378502 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature