Association between cognitive impairment and oral anticancer agent use in older patients with metastatic renal cell carcinoma.

ABSTRACT:

Background

Kidney cancer is the fastest-growing cancer diagnosis in the developed world. About 16% of new cases are stage IV, which has a low five-year survival rate. Many patients with metastatic renal cell carcinoma (mRCC) are older and may have mild cognitive impairment or dementia (MCI/D). Given prior reports of patients with dementia initiating less cancer therapy and the importance of oral anticancer agents (OAAs) in mRCC treatment, we investigated the prevalence of preexisting MCI/D in patients with mRCC and their OAA use.

Methods

SEER-Medicare patients were analyzed who were ≥65 years, diagnosed with mRCC between 2007 and 2015, and had Medicare part D coverage. Patterns and predictors of (a) OAA utilization within the 12 months following mRCC diagnosis and (b) adhere

SUBMITTER: Pritchard JE 

PROVIDER: S-EPMC9378524 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature