Time to target the circadian clock for drug discovery.
Ontology highlight
ABSTRACT:
SUBMITTER: Rasmussen ES
PROVIDER: S-EPMC9378619 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
Time to target the circadian clock for drug discovery.
Rasmussen Emil Sjulstok ES Takahashi Joseph S JS Green Carla B CB
Trends in biochemical sciences 20220513 9
The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse and extensive processes throughout the body. The clock mechanism comprises a core transcription/translation negative feedback loop that is modulated by a complex set of additional interlocking feedback loops. Pharmacological manipulation of the clock may be valuable for treating many maladies including jet lag, shift work and related sleep disorders, various metabolic diseases, and cancer. We review r ...[more]
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