Ontology highlight
ABSTRACT:
SUBMITTER: Schulz R
PROVIDER: S-EPMC9378622 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Schulz Rouven R Korkut-Demirbaş Medina M Venturino Alessandro A Colombo Gloria G Siegert Sandra S
Nature communications 20220815 1
G protein-coupled receptors (GPCRs) regulate processes ranging from immune responses to neuronal signaling. However, ligands for many GPCRs remain unknown, suffer from off-target effects or have poor bioavailability. Additionally, dissecting cell type-specific responses is challenging when the same GPCR is expressed on different cells within a tissue. Here, we overcome these limitations by engineering DREADD-based GPCR chimeras that bind clozapine-N-oxide and mimic a GPCR-of-interest. We show th ...[more]