Selective enhancement of neural coding in V1 underlies fine-discrimination learning in tree shrew.

ABSTRACT: Visual discrimination improves with training, a phenomenon that is thought to reflect plastic changes in the responses of neurons in primary visual cortex (V1). However, the identity of the neurons that undergo change, the nature of the changes, and the consequences of these changes for other visual behaviors remain unclear. We used chronic in vivo 2-photon calcium imaging to monitor the responses of neurons in the V1 of tree shrews learning a Go/No-Go fine orientation discrimination task. We observed increases in neural population measures of discriminability for task-relevant stimuli that correlate with performance and depend on a select subset of neurons with preferred orientations that include the rewarded stimulus and nearby orientations biased away from the non-rewarded stimulus. Lea

SUBMITTER: Schumacher JW 

PROVIDER: S-EPMC9378627 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature