Latent Class Models of Early-life Trauma and Incident Breast Cancer.

ABSTRACT:

Background

Psychosocial trauma has been hypothesized to influence breast cancer risk, but little is known about how co-occurring traumas-particularly during early life-may impact incidence. We examine the relationship between multiple measures of early-life trauma and incident breast cancer.

Methods

The Sister Study is a prospective cohort study of US women (n = 50,884; enrollment 2003-2009; ages 35-74). Of 45,961 eligible participants, 3,070 developed invasive breast cancer or ductal carcinoma in situ through 2017. We assessed trauma before age 18 using previously studied measures (cumulative score, individual trauma type, and substantive domain) and a six-class latent variable to evaluate co-occurring traumas. We accounted for missing data using multiple imputation and est

SUBMITTER: Woo JMP 

PROVIDER: S-EPMC9378657 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature