ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments.

ABSTRACT: Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by gradual loss of memory and cognitive function, which constitutes a heavy burden on the healthcare system globally. Current therapeutics to interfere with the underlying disease process in AD is still under development. Although many efforts have centered on the toxic forms of Aβ to effectively tackle AD, considering the unsatisfactory results so far it is vital to examine other targets and therapeutic approaches as well. The endoplasmic reticulum (ER) stress refers to the build-up of unfolded or misfolded proteins within the ER, thus, perturbing the ER and cellular homeostasis. Emerging evidence indicates that ER stress contributes to the onset and development of AD. A thorough elucidation of ER stress ma

SUBMITTER: Ajoolabady A 

PROVIDER: S-EPMC9378716 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature