Genetic Analyses of Enamel Hypoplasia in Multiethnic Cohorts.

ABSTRACT: Enamel hypoplasia causes reduction in the thickness of affected enamel and is one of the most common dental anomalies. This defect is caused by environmental and/or genetic factors that interfere with tooth formation, emphasizing the importance of investigating enamel hypoplasia on an epidemiological and genetic level. A genome-wide association of enamel hypoplasia was performed in multiple cohorts, overall comprising 7,159 individuals ranging in age from 7-82 years. Mixed-models were used to test for genetic association while simultaneously accounting for relatedness and genetic population structure. Meta-analysis was then performed. More than 5 million single-nucleotide polymorphisms were tested in individual cohorts. Analyses of the individual cohorts and meta-analysis identified associ

SUBMITTER: Alotaibi RN 

PROVIDER: S-EPMC9378791 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature