The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta.

ABSTRACT:

Objective

Osteoblasts are discovered to secrete hormones with endocrine effects on metabolism, and osteocalcin (OC) is the most abundant non-collagenous protein in bone. We investigate the relationship between serum OC levels and glycolipid metabolism and muscle function in children with osteogenesis imperfecta (OI).

Methods

A total of 225 children with OI and 80 healthy controls matched in age and gender were included in this single center study. Serum levels of fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C, HDL-C) were measured by automated analyzers. Serum levels of fasting insulin (FINS) were measured using an automated electrochemiluminescence system. Serum levels of OC and undercarboxylated

SUBMITTER: Zheng WB 

PROVIDER: S-EPMC9378831 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature