Identification of ellagic acid and urolithins as natural inhibitors of Aβ_25-35-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking.

ABSTRACT: Ellagic acid (EA) is a dietary polyphenol that widely exists in grapes, strawberries, and walnuts. It usually exerts multiple biological activities together with its in vivo metabolites called urolithins. EA and urolithins had been proposed as natural agents for applying on the early intervention of Alzheimer's disease (AD). However, the neuroprotective effects of those small molecules have not been confirmed, and the action mechanism is not clear. Deposition of beta-amyloid (Aβ) protein is well documented as being involved in the initiation and pathological process of AD. In the present study, we investigated the attenuating effects of EA and several urolithins on Aβ_25-35-induced neuronal injury and its underlying molecular mechanism by constructing the in vitro A

SUBMITTER: Li HL 

PROVIDER: S-EPMC9378864 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature