A putative causality of vitamin D in common diseases: A mendelian randomization study.

ABSTRACT:

Backgrounds

Vitamin D is considered as a nutrient protecting individuals against an array of diseases based on observational studies. Such a protective effect, however, has not been demonstrated by randomized controlled trials. This study aims to explore a putative causal role of vitamin D in common diseases through a two-sample Mendelian randomization (MR) framework.

Methods

Circulating vitamin D was predicted by 41 genetic variants discovered in European populations. Common diseases were verified through two ways, using information from Japanese patients of Biobank Japan and using information from European patients of FinnGen project. We additionally validated the results by replacing vitamin D-associated instrumental variables (IVs) of European population with that of an

SUBMITTER: Liu H 

PROVIDER: S-EPMC9378956 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature