Id2 exerts tumor suppressor properties in lung cancer through its effects on cancer cell invasion and migration.

ABSTRACT:

Background

Despite advances in prognosis and treatment of lung adenocarcinoma (LADC), a notable non-small cell lung cancer subtype, patient outcomes are still unsatisfactory. New insight on novel therapeutic strategies for LADC may be gained from a more comprehensive understanding of cancer progression mechanisms. Such strategies could reduce the mortality and morbidity of patients with LADC. In our previous study, we performed cDNA microarray screening and found an inverse relationship between inhibitor of DNA binding 2 (Id2) expression levels and the invasiveness of LADC cells.

Materials and methods

To identify the functional roles of Id2 and its action mechanisms in LADC progression, we successfully established several Id2-overexpressing and Id2-silenced LADC cell clones.

SUBMITTER: Chen JT 

PROVIDER: S-EPMC9379288 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature