Clinical and immunological characteristics of Aspergillus fumigatus-sensitized asthma and allergic bronchopulmonary aspergillosis.

ABSTRACT:

Background

Aspergillus fumigatus (A.f) is a common airborne allergen that contributes to allergic asthma. In some patients, A.f can colonize in the airway and lead to allergic bronchopulmonary aspergillosis (ABPA). However, our understanding of the pathogenesis of A.f-sensitized asthma and ABPA remains inadequate.

Objective

We aimed to investigate the clinical and immunological characteristics of A.f-sensitized asthma and ABPA.

Methods

A total of 64 ABPA and 57 A.f-sensitized asthma patients were enrolled in the study, and 33 non-A.f-sensitized asthma patients served as the control group. The clinical and immunological parameters included lung function, fractional exhaled nitric oxide (FeNO), induced sputum and blood ce

SUBMITTER: Chen H 

PROVIDER: S-EPMC9379317 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature