Animal Models of Choroidal Neovascularization: A Systematic Review.

ABSTRACT:

Purpose

Animal models of choroidal neovascularization (CNV) are extensively used to characterize the pathophysiology of chorioretinal diseases with CNV formation and to evaluate novel treatment strategies. This systematic review aims to give a detailed overview of contemporary animal models of CNV.

Methods

A systematic search was performed in PubMed and EMBASE from November 20, 2015, to November 20, 2020, for mammalian animal models of CNV. Following inclusion by two investigators, data from the articles were extracted according to a predefined protocol.

Results

A total of 380 full articles, representing 409 independent animal models, were included. Mice were by far the most utilized animal (76%) followed by rats and non-human primates. The median age of rodents was 8

SUBMITTER: Fabian-Jessing BK 

PROVIDER: S-EPMC9379329 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature