Platelet-derived microRNA-223 attenuates TNF-α induced monocytes adhesion to arterial endothelium by targeting ICAM-1 in Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease (KD) is an acute vasculitis that may result in permanent coronary artery damage with unknown etiology. Endothelial cell (EC) dysfunction and platelet hyperactivity are the hallmarks of KD. Platelets are involved in the development of endothelial dysfunction. MiR-223 transferred by platelet microparticles (PMPs) has been found to involve in the functional regulation of endothelial cells in sepsis. However, the role of platelet-derived miR-223 in endothelial dysfunction has not yet been investigated in KD.

Objectives

We seek to investigate the role of platelet-derived miR-223 in endothelial dysfunction of KD vasculopathy.

Methods and results

Forty-five acute KD patients and 45 matched controls were randomly recruited in the study. When co-cul

SUBMITTER: Guo M 

PROVIDER: S-EPMC9379370 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature