Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid.

ABSTRACT:

Background

The AT(N) classification was proposed for categorising individuals according to biomarkers. However, AT(N) profiles may vary depending on the markers chosen and the target population.

Methods

We stratified 177 individuals who participated in the Japanese Alzheimer's Disease Neuroimaging Initiative by AT(N) classification according to cerebrospinal fluid (CSF) biomarkers. We compared the frequency of AT(N) profiles between the classification using total tau and neurofilament light chain (NfL) as N markers (AT(N)_tau and AT(N)_NfL). Baseline characteristics, and longitudinal biological and clinical changes were examined between AT(N) profiles.

Results

We found that 9% of cognitively unimpaired subjects, 49% of subjects with mild cognitive

SUBMITTER: Kasuga K 

PROVIDER: S-EPMC9379489 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature