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Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model.


ABSTRACT: Bone growth occurs in the epiphyseal growth plate (EGP) and epiphyseal growth plate cells (EGPCs) exist in EGP. EGPCs, including skeletal stem cells (SSCs), are cells that induce bone growth and development through endochondral ossification. Recently, the superiority of bone regeneration through endochondral ossification has been reported. Our study compared EGPCs with bone marrow-derived mesenchymal stem cells (BM-MSCs) and suggested the therapeutic potential of new bone regeneration. In this study, we analyzed the characteristics between EGPCs and BM-MSCs based on morphological characteristics and molecular profiles. EGPCs expressed chondrogenic and osteogenic markers higher than BM-MSCs. Additionally, in co-culture with BM-MSCs, EGPCs induced an increase in chondrogenic, osteogenic, and hypertrophic markers of BM-MSCs. Finally, EGPCs induced higher bone regeneration than BM-MSCs in the osteoporosis model. Overall, we suggest the possibility of EGPCs as cell therapy for effective bone regeneration.

SUBMITTER: Baek I 

PROVIDER: S-EPMC9379561 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature

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Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model.

Baek Inho I   Bello Alvin Bacero AB   Jeon Jieun J   Arai Yoshie Y   Cha Byung-Hyun BH   Kim Byoung Ju BJ   Lee Soo-Hong SH  

Journal of tissue engineering 20220101


Bone growth occurs in the epiphyseal growth plate (EGP) and epiphyseal growth plate cells (EGPCs) exist in EGP. EGPCs, including skeletal stem cells (SSCs), are cells that induce bone growth and development through endochondral ossification. Recently, the superiority of bone regeneration through endochondral ossification has been reported. Our study compared EGPCs with bone marrow-derived mesenchymal stem cells (BM-MSCs) and suggested the therapeutic potential of new bone regeneration. In this s  ...[more]

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