The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology.

ABSTRACT:

Objective

Coactivator-associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of arginine residues on target proteins to regulate critical processes in health and disease. A mechanistic understanding of the role(s) of CARM1 in skeletal muscle biology is only gradually emerging. The purpose of this study was to elucidate the function of CARM1 in regulating the maintenance and plasticity of skeletal muscle.

Methods

We used transcriptomic, methylproteomic, molecular, functional, and integrative physiological approaches to determine the specific impact of CARM1 in muscle homeostasis.

Results

Our data defines the occurrence of arginine methylation in skeletal muscle and demonstrates that this mark occurs on par with phosphorylation and ubiquitination. CAR

SUBMITTER: vanLieshout TL 

PROVIDER: S-EPMC9379683 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature