Association of Chronic Kidney Disease With Risk of Intracerebral Hemorrhage.

ABSTRACT:

Importance

The evidence linking chronic kidney disease (CKD) to spontaneous intracerebral hemorrhage (ICH) is inconclusive owing to possible confounding by comorbidities that frequently coexist in patients with these 2 diseases.

Objective

To determine whether there is an association between CKD and ICH risk.

Design, setting, and participants

A 3-stage study that combined observational and genetic analyses was conducted. First, the association between CKD and ICH risk was tested in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study, a multicenter case-control study in the US. All participants with available data on CKD from ERICH were included. Second, this analysis was replicated in the UK Biobank (UKB), an ongoing population study in the UK. All p

SUBMITTER: Vanent KN 

PROVIDER: S-EPMC9379821 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature