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Convergent Synthesis of Dihydrobenzofurans via Urea Ligand-Enabled Heteroannulation of 2-Bromophenols with 1,3-Dienes.

ABSTRACT: We disclose a palladium and urea ligand-mediated heteroannulation of 2-bromophenols and 1,3-dienes. This method addresses synthetic challenges present in the palladium-catalyzed heteroannulation of bifunctional reagents and olefins by engaging a diverse scope of coupling partners under a unified set of reaction conditions. Our recently developed urea ligand platform outperforms phosphine ligands to generate the dihydrobenzofuran motif in a convergent manner.

SUBMITTER: Houghtling KE

PROVIDER: S-EPMC9380016 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Convergent Synthesis of Dihydrobenzofurans via Urea Ligand-Enabled Heteroannulation of 2-Bromophenols with 1,3-Dienes.

Houghtling Kaitlyn E KE Canfield Amanda M AM Paradine Shauna M SM

Organic letters 20220729 31

We disclose a palladium and urea ligand-mediated heteroannulation of 2-bromophenols and 1,3-dienes. This method addresses synthetic challenges present in the palladium-catalyzed heteroannulation of bifunctional reagents and olefins by engaging a diverse scope of coupling partners under a unified set of reaction conditions. Our recently developed urea ligand platform outperforms phosphine ligands to generate the dihydrobenzofuran motif in a convergent manner. ...[more]

PMID: 35904546

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