A novel use of biomechanical model-based deformable image registration (DIR) for assessing colorectal liver metastases ablation outcomes.

ABSTRACT:

Purpose

Colorectal cancer is the third most common form of cancer in the United States, and up to 60% of these patients develop liver metastasis. While hepatic resection is the curative treatment of choice, only 20% of patients are candidates at the time of diagnosis. While percutaneous thermal ablation (PTA) has demonstrated 24%-51% overall 5-year survival rates, assurance of sufficient ablation margin delivery (5 mm) can be challenging, with current methods of 2D distance measurement not ensuring 3D minimum margin. We hypothesized that biomechanical model-based deformable image registration (DIR) can reduce spatial uncertainties and differentiate local tumor progression (LTP) patients from LTP-free patients.

Methods

We retrospectively acquired 30 patients (16 LTP and 14 LT

SUBMITTER: Anderson BM 

PROVIDER: S-EPMC9380122 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature