Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Stolp Andersen M
PROVIDER: S-EPMC9380131 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
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Dissecting the limited genetic overlap of Parkinson's and Alzheimer's disease.
Stolp Andersen Maren M Tan Manuela M Holtman Inge R IR Hardy John J Pihlstrøm Lasse L
Annals of clinical and translational neurology 20220609 8
Parkinson's disease and Alzheimer's disease show overlapping features both clinically and neuropathologically and elucidating shared mechanisms could have important implications for therapeutic strategies. Evidence for genetic overlap is limited, although enrichment of heritability in genomic regions relevant to microglia has been demonstrated in both disorders. Using summary statistics from genome-wide association studies, we assessed genetic covariance stratified by cell types and local geneti ...[more]
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