Upregulation of RCAN1.4 by HIF1α alleviates OGD-induced inflammatory response in astrocytes.

ABSTRACT:

Objective

Ischemic stroke is a leading cause of human mortality and long-term disability worldwide. As one of the main forms of regulator of calcineurin 1 (RCAN1), the contribution of RCAN1.4 in diverse biological and pathological conditions has been implicated. But the role of RCAN1.4 in ischemic stroke progression remains elusive. This study is to explore the expression changes and roles of RCAN1.4 in ischemic stroke as well as the underlying mechanisms for these changes and effects of RCAN1.4 in ischemic stroke.

Methods

Middle cerebral artery occlusion model in C57BL/6J mice and oxygen-glucose deprivation (OGD) model in primary astrocytes were performed to induce the cerebral ischemic stroke. The expression pattern of RCAN1.4 was assessed using real-time quantitative PCR

SUBMITTER: Yang X 

PROVIDER: S-EPMC9380140 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature