Epigenetic age predictors in community-dwelling adults with high impact knee pain.

ABSTRACT: Gerontological research reveals considerable interindividual variability in aging phenotypes, and emerging evidence suggests that high impact chronic pain may be associated with various accelerated biological aging processes. In particular, epigenetic aging is a robust predictor of health-span and disability compared to chronological age alone. The current study aimed to determine whether several epigenetic aging biomarkers were associated with high impact chronic pain in middle to older age adults (44-78 years old). Participants (n = 213) underwent a blood draw, demographic, psychosocial, pain and functional assessments. We estimated five epigenetic clocks and calculated the difference between epigenetic age and chronological age, which has been previously reported to predict overa

SUBMITTER: Cruz-Almeida Y 

PROVIDER: S-EPMC9380216 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature