Antioxidant procyanidin B2 protects oocytes against cryoinjuries via mitochondria regulated cortical tension.

ABSTRACT:

Background

Irreversible cryodamage caused by oocyte vitrification limited its wild application in female fertility preservation. Antioxidants were always used to antagonist the oxidative stress caused by vitrification. However, the comprehensive mechanism underlying the protective role of antioxidants has not been studied. Procyanidin B2 (PCB2) is a potent natural antioxidant and its functions in response to vitrification are still unknown. In this study, the effects of PCB2 on vitrified-thawed oocytes and subsequent embryo development were explored, and the mechanisms underlying the protective role of PCB2 were systematically elucidated.

Results

Vitrification induced a marked decline in oocyte quality, while PCB2 could improve oocyte viability and further development after

SUBMITTER: Zhuan Q 

PROVIDER: S-EPMC9380387 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature