Lineage tracing shows that cell size asymmetries predict the dorsoventral axis in the sea star embryo.

ABSTRACT:

Background

Cell size asymmetries are often linked to cell fate decisions, due to cell volumes and cell fate determinants being unequally partitioned during asymmetric cell divisions. A clear example is found in the sea urchin embryo, where a characteristic and obvious unequal 4th cleavage generates micromeres, which are necessary for mesendoderm cell fate specification. Unlike sea urchin development, sea star development is generally thought to have only equal cleavage. However, subtle cell size asymmetries can be observed in sea star embryos; whether those cell size asymmetries are consistently produced during sea star development and if they are involved in cell fate decisions remains unknown.

Results

Using confocal live imaging of early embryos we quantified cell size asy

SUBMITTER: Barone V 

PROVIDER: S-EPMC9380389 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature