Assessment of causal effects of visceral adipose tissue on risk of cancers: a Mendelian randomization study.

ABSTRACT:

Background

Despite the established association between obesity and cancer risk, it remains unclear whether visceral obesity is causally related to cancer risk and whether it is more pro-oncogenic than total body fat.

Methods

We conducted two-sample Mendelian randomization (MR) analysis to assess the causal effects of visceral adipose tissue (VAT) on six common cancers. For exposure data, 221 genetic variants associated with the predicted volume of VAT in 325 153 Europeans from UK Biobank were used as instrumental variables. Genetic association data of six common cancers (breast, lung, colorectal, ovarian, pancreatic and prostate cancers) were obtained from large-scale consortia with an average of 19 576 cases and 43 272 controls. We performed univariable MR with five MR meth

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9380424 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature