Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet.

ABSTRACT:

Objective

Reducing FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) can be clinically beneficial in IBS but the mechanism is incompletely understood. We aimed to detect microbial signatures that might predict response to the low FODMAP diet and assess whether microbiota compositional and functional shifts could provide insights into its mode of action.

Design

We used metagenomics to determine high-resolution taxonomic and functional profiles of the stool microbiota from IBS cases and household controls (n=56 pairs) on their usual diet. Clinical response and microbiota changes were studied in 41 pairs after 4 weeks on a low FODMAP diet.

Results

Unsupervised analysis of baseline IBS cases pre-diet identified two distinct microbiota prof

SUBMITTER: Vervier K 

PROVIDER: S-EPMC9380505 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature