Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids.

ABSTRACT:

Objectives

Giant cell arteritis (GCA) is a complex systemic vasculitis mediated by the interplay between both genetic and epigenetic factors. Monocytes are crucial players of the inflammation occurring in GCA. Therefore, characterisation of the monocyte methylome and transcriptome in GCA would be helpful to better understand disease pathogenesis.

Methods

We performed an integrated epigenome-and transcriptome-wide association study in CD14+ monocytes from 82 patients with GCA, cross-sectionally classified into three different clinical statuses (active, in remission with or without glucocorticoid (GC) treatment), and 31 healthy controls.

Results

We identified a global methylation and gene expression dysregulation in GCA monocytes. Specifically, monocytes from active pat

SUBMITTER: Estupinan-Moreno E 

PROVIDER: S-EPMC9380516 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature