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NDM-35-Producing ST167 Escherichia coli Highly Resistant to β-Lactams Including Cefiderocol.

ABSTRACT: A multidrug-resistant (carbapenems, aztreonam + avibactam, and cefiderocol) ST167 Escherichia coli clinical isolate recovered from a patient hospitalized in Switzerland produced NDM-35 showing ca. 10-fold increased hydrolytic activity toward cefiderocol compared to NDM-1. The isolate co-produced a CMY-type β-lactamase, exhibited a four amino-acid insertion in PBP3, and possessed a truncated iron transporter CirA protein. Our study identified an association of unrelated resistance mechanisms leading to resistance to virtually all β-lactams in a high-risk E. coli clone.

SUBMITTER: Poirel L

PROVIDER: S-EPMC9380521 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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NDM-35-Producing ST167 Escherichia coli Highly Resistant to β-Lactams Including Cefiderocol.

Poirel Laurent L Ortiz de la Rosa José Manuel JM Sakaoglu Zeynep Z Kusaksizoglu Ayda A Sadek Mustafa M Nordmann Patrice P

Antimicrobial agents and chemotherapy 20220711 8

A multidrug-resistant (carbapenems, aztreonam + avibactam, and cefiderocol) ST167 Escherichia coli clinical isolate recovered from a patient hospitalized in Switzerland produced NDM-35 showing ca. 10-fold increased hydrolytic activity toward cefiderocol compared to NDM-1. The isolate co-produced a CMY-type β-lactamase, exhibited a four amino-acid insertion in PBP3, and possessed a truncated iron transporter CirA protein. Our study identified an association of unrelated resistance mechanisms lead ...[more]

PMID: 35867524

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