Neutrophil heterogeneity in complement C1q expression associated with sepsis mortality.

ABSTRACT: Sepsis is a life-threatening systemic inflammatory condition causing approximately 11 million annual deaths worldwide. Although key hyperinflammation-based organ dysfunctions that drive disease pathology have been recognized, our understanding of the factors that predispose patients to septic mortality is limited. Due to the lack of reliable prognostic measures, the development of appropriate clinical management that improves patient survival remains challenging. Here, we discovered that a subpopulation of CD49c^high neutrophils with dramatic upregulation of the complement component 1q (C1q) gene expression arises during severe sepsis. We further found that deceased septic patients failed to maintain C1q protein expression in their neutrophils, whereas septic survivors expressed

SUBMITTER: Trzeciak A 

PROVIDER: S-EPMC9380571 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature