Comparison of the Tissue Distribution of a Long-Circulating Glucagon-like Peptide-1 Agonist Determined by Positron Emission Tomography and Quantitative Whole-Body Autoradiography.

ABSTRACT: Positron emission tomography (PET) is a molecular imaging modality that enables non-invasive visualization of tracer distribution and pharmacology. Recently, peptides with long half-lives allowed once-a-week dosing of glucagon-like peptide-1 receptor (GLP-1R) agonists with therapeutic applications in diabetes and obesity. PET imaging for such long-lived peptides is hindered by the typically used short-lived radionuclides. Zirconium-89 (⁸⁹Zr) emerged as a promising PET radionuclide with a sufficiently long half-life to be applied for biodistribution studies of long-circulating biomolecules. A comparison between the biodistribution profiles obtained via ⁸⁹Zr-PET and the current standard, quantitative whole-body autoradiography (QWBA), will be valuable for the developmen

SUBMITTER: Fernandes EFA 

PROVIDER: S-EPMC9380726 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature