Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development.

ABSTRACT: Transposable elements (TEs) contribute to the evolution of gene regulatory networks and are dynamically expressed throughout human brain development and disease. One gene regulatory mechanism influenced by TEs is the miRNA system of post-transcriptional control. miRNA sequences frequently overlap TE loci and this miRNA expression landscape is crucial for control of gene expression in adult brain and different cellular contexts. Despite this, a thorough investigation of the spatiotemporal expression of TE-embedded miRNAs in human brain development is lacking. Here, we identify a spatiotemporally dynamic TE-embedded miRNA expression landscape between childhood and adolescent stages of human brain development. These miRNAs sometimes arise from two apposed TEs of the same subfamily, such as fo

SUBMITTER: Playfoot CJ 

PROVIDER: S-EPMC9380744 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature