Non-linear association between serum spermidine and mild cognitive impairment: Results from a cross-sectional and longitudinal study.

ABSTRACT:

Background

Although animal studies show that spermidine (SPD) affects cognitive function, the relevant evidence among humans is limited. We aim to examine the association between serum SPD levels and cognitive performance.

Materials and methods

We conducted a cross-sectional and longitudinal study including a baseline and one follow-up survey. The baseline survey was conducted from June 2019 to August 2019, while the follow-up survey was conducted from June 2021 to August 2021. We analyzed 3,774 adult participants aged >35 years, who had no history of dementia.

Results

The mean (SD) age of the participants was 57.4 (9.8) years. Relative to the first tertile, the multivariate-adjusted ORs (95% CIs) of mild cognitive impairment (MCI) for the second and third tertile gro

SUBMITTER: Xu J 

PROVIDER: S-EPMC9380894 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature