Connected speech markers of amyloid burden in primary progressive aphasia.

ABSTRACT:

Introduction

Positron emission tomography (PET) amyloid imaging has become an important part of the diagnostic workup for patients with primary progressive aphasia (PPA) and uncertain underlying pathology. Here, we employ a semi-automated analysis of connected speech (CS) with a twofold objective. First, to determine if quantitative CS features can help select primary progressive aphasia (PPA) patients with a higher probability of a positive PET amyloid imaging result. Second, to examine the relevant group differences from a clinical perspective.

Methods

117 CS samples from a well-characterised cohort of PPA patients who underwent PET amyloid imaging were collected. Expert consensus established PET amyloid status for each patient, and 40% of the sample was amyloid positive.<

SUBMITTER: Slegers A 

PROVIDER: S-EPMC9381031 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature