Increased proportion of follicular helper T cells is associated with B cell activation and disease severity in IgA nephropathy.

ABSTRACT: IgA nephropathy (IgAN) is the most common primary glomerulonephritis, characterized by glomerular deposition of IgA immune complexes, mainly produced by B cells under the regulation of CD4⁺T cells. However, the alterations of specific CD4⁺T cell subsets and the mechanism of B cells activation in IgAN remain unclear. Therefore, we aimed to investigate the landscape characteristics and role of CD4⁺T cells in the progression of IgAN. We identified that the proportion of Th2, Th17 and Tfh (follicular helper T) cells in patients with IgAN was significantly higher than that of healthy controls (P < 0.05). Single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) showed that Th cells and B cells in patients with IgAN were more activated. Corr

SUBMITTER: Du W 

PROVIDER: S-EPMC9381139 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature