Combined quantitative T2 mapping and [¹⁸F]FDG PET could improve lateralization of mesial temporal lobe epilepsy.

ABSTRACT:

Objectives

To investigate whether quantitative T2 mapping is complementary to [¹⁸F]FDG PET in epileptogenic zone detection, thus improving the lateralization accuracy for drug-resistant mesial temporal lobe epilepsy (MTLE) using hybrid PET/MR.

Methods

We acquired routine structural MRI, T2-weighted FLAIR, whole brain T2 mapping, and [¹⁸F]FDG PET in 46 MTLE patients and healthy controls on a hybrid PET/MR scanner, followed with computing voxel-based z-score maps of patients in reference to healthy controls. Asymmetry indexes of the hippocampus were calculated for each imaging modality, which then enter logistic regression models as univariate or multivariate for lateralization. Stereoelectroencephalography (SEEG) recordings and clinical decisions were co

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9381472 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature