Integrase Inhibitors are Associated with Neuropsychiatric Symptoms in Women with HIV.

ABSTRACT:

Objective

Women with HIV(WWH) are more likely to discontinue/change antiretroviral therapy(ART) due to side effects including neuropsychiatric symptoms. Efavirenz and integrase strand transfer inhibitors(INSTIs) are particularly concerning. We focused on these ART agents and neuropsychiatric symptoms in previously developed subgroups of WWH that differed on key sociodemographic factors as well as longitudinal behavioral and clinical profiles. WWH from the Women's Interagency HIV Study were included if they had ART data available, completed the Perceived Stress Scale-10 and PTSD Checklist-Civilian. Questionnaires were completed biannually beginning in 2008 through 2016. To examine ART-symptom associations, constrained continuation ratio model via penalized maximum likelihood were fi

SUBMITTER: Rubin LH 

PROVIDER: S-EPMC9381649 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature