Efficacy and safety of radiotherapy/chemoradiotherapy combined with immune checkpoint inhibitors for locally advanced stages of esophageal cancer: A systematic review and meta-analysis.

ABSTRACT:

Background

Radiotherapy (RT)/Chemoradiotherapy (CRT) are important treatments for all stages of esophageal cancer (EC). The combination of immune checkpoint inhibitors (ICIs) with RT/CRT seems to be promising avenue for the treatment of EC. Therefore, a systematic review and meta-analysis was performed in order to assess the safety and efficacy of RT/CRT and ICI combination therapy for EC patients.

Methods

PubMed and several other databases were searched (according to specific criteria) to find relevant studies published prior to the 31^st of December 2021.

Results

1962 articles were identified for screening, and six trials containing 668 patients were identified and pooled to determine the one- and two-year overall survival (OS), which were 84.5% (95% confi

SUBMITTER: Wu J 

PROVIDER: S-EPMC9381695 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature