Remote cortical atrophy and language outcomes after chronic left subcortical stroke with aphasia.

ABSTRACT:

Objective

Subcortical stroke can cause a variety of language deficits. However, the neural mechanisms underlying subcortical aphasia after stroke remain incompletely elucidated. We aimed to determine the effects of distant cortical structures on aphasia outcomes and examine the correlation of cortical thickness measures with connecting tracts integrity after chronic left subcortical stroke.

Methods

Thirty-two patients and 30 healthy control subjects underwent MRI scanning and language assessment with the Western Aphasia Battery-Revised (WAB-R) subtests. Among patients, the cortical thickness in brain regions that related to language performance were assessed by the FreeSurfer software. Fiber tracts connecting the identified cortical regions to stroke lesions were reconstruct

SUBMITTER: Tang H 

PROVIDER: S-EPMC9381815 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature