Home EEG sleep assessment shows reduced slow-wave sleep in mild-moderate Alzheimer's disease.

ABSTRACT:

Introduction

Sleep disturbances are common in Alzheimer's disease (AD), with estimates of prevalence as high as 65%. Recent work suggests that specific sleep stages, such as slow-wave sleep (SWS) and rapid eye movement (REM), may directly impact AD pathophysiology. A major limitation to sleep staging is the requirement for clinical polysomnography (PSG), which is often not well tolerated in patients with dementia. We have recently developed a deep learning model to reliably analyze lower quality electroencephalogram (EEG) data obtained from a simple, two-lead EEG headband. Here we assessed whether this methodology would allow for home EEG sleep staging in patients with mild-moderate AD.

Methods

A total of 26 mild-moderate AD patients and 24 age-matched, healthy control parti

SUBMITTER: Kent BA 

PROVIDER: S-EPMC9381912 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature