Potential modifiable factors associated with late-life cognitive trajectories.

ABSTRACT:

Objective

There is variability across individuals in cognitive aging. To investigate the associations of several modifiable factors with high and low cognitive performance.

Methods

Data came from 17,724 community-dwelling individuals aged 65-98 years. Global cognition, verbal fluency, episodic memory, and psychomotor speed were assessed over up to seven years. Group-based multi-trajectory modeling identified distinct cognitive trajectories. Structural equation modeling examined the direct/indirect associations of social/behavioral factors and several chronic conditions with cognitive trajectories.

Results

Seven trajectory subgroups were identified. In the structural equation modeling we compared two subgroups-participants with the highest (14.2%) and lowest (4.1%) cog

SUBMITTER: Wu Z 

PROVIDER: S-EPMC9381981 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature